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Senior Scientist, Bioseparation R&D

Senior Scientist, Bioseparation R&D

  • 2021-23070.3
  • Hercules, California, United States

This is an opening for a recent PHD graduate with strong background in the separation and characterization of biomolecules, who is interested in applying basic scientific/engineering principles to the large scale production of biopharmaceuticals. The qualified candidate will support our efforts in the design, evaluation, manufacture transfer, and applications of new chromatographic resins and membranes for the preparation of highly pure biomolecules including proteins, nucleic acids and viruses to be used as therapeutic agents.

Responsibilities

  • Contribute to the design and evaluation of new resins and membranes, including physical/chemical characterization, and applications in the separation/preparation of new/novel biological molecules of pharmaceutical interest.
  • Work actively in the laboratory, on evaluation of chromatography media and membranes  for the binding and recovering of target molecule, clearance of impurities, regeneration and storage, chemical and physical stability; verification and validation during production scale-up; and packing process-scale columns to demonstrate the scalability of new resins/membranes.
  • Interface with manufacturing plant for process transfer and addressing product quality issues as needed.
  • Interface with Marketing/Sales colleagues on chromatography media promotion and technical support.

Qualifications

We are looking for candidates with the following credentials:

  • Recent PhD graduates (0 ~ 3 years) in life science (biochemistry/protein chemistry or related field) with prior experience in the purification/preparation of proteins, nucleic acids, viruses/VLPs, and/or bacteriophages from cell culture, or in chemical engineering/material science with focus on molecular interaction, structure-function correlation, and biomolecules separation.
  • Broad knowledge and skills in proteins, nucleic acids or other biological molecules sample preparation, analysis, separation and characterization.
  • Demonstrated proficiency in problem-solving, data analysis and basic troubleshooting of experimental problems; motivated and capable of performing exploratory research independently.
  • Track record of publications and strong technical presentation skills.

Highly Desired Skills:

  • Hands-on experience in the expression and purification of biological molecules (proteins, nucleic acids, viruses/VLPs) using chromatography and membrane filtration methods; experience in the preparation of long-length DNA/RNA and viral vectors a plus.
  • Experience in protein/nucleic purity and quantity analysis (qPCR/ddPCR, NGS, SDS-PAGE, HPLC, UV-vis, fluorimetry, ELISA, Western hybridization, protein ID) and protein quantitation and activity assays; working knowledge of protein and DNA sequence analysis/alignment, primer design, protein 3D structure and protein-protein interaction modeling software a plus.
  • Expertise in the characterization of biomolecules’ absorption by/desorption from solid surface.
  • Working knowledge of gene cloning/expression, random or site-directed mutagenesis.
  • Ability to work in a multi-disciplinary team, as an independent researcher; ability to provide technical guidance to junior team members.

 

Vaccination Requirement:

 

Due to the higher threat of more infectious and deadly COVID-19 variant strains emerging, Bio-Rad recently announced a new mandatory vaccination policy requiring its US employees to be fully vaccinated against COVID-19 as a condition of employment. Bio-Rad will make reasonable accommodations for valid exemptions based on disability, medical, or religious reasons. With this policy, Bio-Rad joins a growing list of companies that are prioritizing sound science and available facts to best ensure the ongoing safety of its employees and the community.

 

About Bio-Rad:

 

Bio-Rad is a global leader providing a broad array of clinical diagnostics and life science research products. With a team of more than 8,000 employees and a global network of operations serving our customers, we help people live longer, healthier lives.

 

Bio-Rad was founded over six decades ago and has continued to provide the healthcare industry with innovative and useful products that help life science researchers accelerate the discovery process and medical diagnostic labs obtain faster, better results.

 

EEO/AA Employer/Veterans/Disabled/Race/Ethnicity/Gender/Age

 

Agency Non-Solicitation: 

 

Bio-Rad does not accept agency resumes, unless the agency has been authorized by a Bio-Rad Recruiting Representative. Please do not submit resumes unless authorized to do so. Bio-Rad will not pay for any fees related to unsolicited resumes.

 

 

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